Re: [R] Survival analysis: same subject with multiple treatments

From: Terry Therneau <therneau_at_mayo.edu>
Date: Mon, 25 Apr 2011 08:20:56 -0500


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I need some help to figure out what is the proper model in survival analysis
for my data.
Subjects were randomized to 3 treatments in trial 1, some of them experience
the event during the trial;
After period of time those subjects were randomized to 3 treatments again in
trial 2, but different from what they got in 1st trial, some of them experience the event during the 2nd trial (I think the carryover effect can
be ignored since the time between two trials is long enough.)
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If it were me I would add cluster(subject) to the model. Multiple events/subject is not simple, however, and you should find a book chapter to read.

Terry Therneau



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