Re: [R] exact 95% confidence intervals

From: Frank E Harrell Jr <f.harrell_at_vanderbilt.edu>
Date: Wed 27 Sep 2006 - 12:30:10 GMT

Peter Dalgaard wrote:
> "XinMeng" <xmeng@capitalbio.com> writes:
>

>> Hello sir:

>
>> As to the 2*2 table format for reporting results comparing a new
>> test to true diagnosis,when I got the sensitivity and
>> specificity,how can I calculate the exact 95% confidence intervals
>> (based on the binomial distribution) for sensitivity and specificity
>> via R?

>
> Just run binom.test on the data from each column (or row, depending on
> which way you turn the tables).
>

But beware of exact binomial intervals - they are often not very accurate. Wilson and other intervals are generally better. For example see the binconf function in the Hmisc package.

-- 
Frank E Harrell Jr   Professor and Chair           School of Medicine
                      Department of Biostatistics   Vanderbilt University

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Received on Wed Sep 27 22:36:07 2006

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