# [R] Huge number

From: Hyojin Lee <hyojinl_at_bcgsc.ca>
Date: Mon, 18 Feb 2008 15:23:18 -0800

Hi,
I'm trying to calculate p-value to findout definitely expressed genes compare A to B situation.
I got this data(this is a part of data) from whole organism , and each number means each expression values (that means, we could think 'a' gene is 13 in A situation, and it turns 30 in B situation) To findout probability, I'm going to use Audic - Claverie Method. ( The significance of digital gene expression profiles. 1997)

But using this equation p(x|y), I have to calculate (x+y)! first. but I can't calculate (157+221)! or (666+1387)! in R. That's probabily the handling problem of huge number, How could I calculate p value in this data with R?

```                         A             B
Total	 5874641	 6295980
a	 13	 30
b	 36	 39
c	 0	 5
d	 40	 61
e	 16	 20
f	 13	 11
g	 3	 3
h	 9	 5
i	 12	 35
j	 157	 221
k	 17	 39
l	 6	 17
m	 666	 1387
n	 2	 5

```

The significance of digital gene expression profiles.

Audic S
<http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22A
udic%20S%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_Result sPanel.Pubmed_RVAbstractPlusDrugs1> , Claverie JM
<http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22C
laverie%20JM%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_Re sultsPanel.Pubmed_RVAbstractPlusDrugs1> .

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