[R] Vacancy Post Doc PK-PD modeling the Netherlands

From: beukerspkpd <beukerspkpd_at_lacdr.leidenuniv.nl>
Date: Fri, 28 Mar 2008 14:34:58 +0100

Post-Doctoral Fellowship
Modelling of Cardiovascular Safety (full time) Leiden University, Leiden, The Netherlands  


Job description

TOP Institute Pharma (TI Pharma) has granted our proposal to set up a mechanism-based PKPD modelling platform. This platform focuses on the transfer of knowledge from academia to the pharmaceutical industry and is a collaborative effort of four excellent academic institutes and six leading global pharmaceutical industries. Unique to this platform is the availability of shared databases on disease and drug related parameters.

The aim of the platform is to provide a scientific basis for rational drug discovery and development with a strong focus on priority medicines. In total 11 PhD students and 7 post-doctoral fellows are employed by the platform. Three working groups have been established which will address the following challenges 1) to develop mechanism-based PKPD models to characterise disease progression, 2) to predict the effects of ageing on clinical response and 3) to create a translational research framework that allows extrapolation of preclinical to clinical and epidemiological findings. The approach is based on hierarchical models and relies on the use of advanced statistical software tools such as NONMEM, WINBUGS and R.

To ensure the development of a conceptual research framework beyond the specific scientific questions being addressed by the working groups and enable cross-fertilisation of skills, a position has been created for a post doctoral fellow. The main objective of this program is to evaluate how cardiovascular safety findings in phase III clinical trials correlate to long term safety in longitudinal (epidemiology) studies. >From a methodological perspective, this investigation is aimed at evaluating new parameterisations for drug exposure and integration of PKPD concepts into the assessment of risk.


The post-doctoral fellow should have the following background and competencies:


The Leiden Division of Pharmacology at the Leiden/Amsterdam Center for Drug Research (LACDR) has a long-standing expertise in the development of Pharmacokinetic/Pharmacodynamic (PKPD) models to predict efficacy and safety of drugs. Given the nature of this project, the main task of the principal post-doctoral fellow will be to coach the PhD students and postdocs within the platform, to support model building and simulation and to identify underlying general principles shared among individual projects.

Conditions of employment

The employment for this position will be full time for 4 years.

Additional conditions of employment:
You will work as a team member of a TI Pharma project. The project team comprises academic and industrial partners. In this case, the partners are: University of Leiden, University of Groningen, the University Medical Center of Utrecht, the Erasmus Medical Center, Rotterdam and the companies Eli Lilly, Johnson & Johnson, GSK, Nycomed, Organon/Schering Plough and Pfizer. You will attend a unique drug discovery education and training program offered by TI Pharma.
Additional Information

Additional information can be obtained through one of the following links:
Application You can apply by sending your application to: Contact person
Dr. O. Della Pasqua
Division of Pharmacology, Leiden/Amsterdam Center for Drug Research Leiden, The Netherlands
+44 7876031907

Margot Beukers, PhD
Project Manager
TI Pharma PK PD Modeling Platform
Availability (CET):
Monday: 12.30 - 16.30
Wednesday: 07.30 -16.30
Thursday: 07.30 -11.30
Friday: 12.30 - 16.30  

Gorlaeus Laboratories, HB811, Leiden University Einsteinweg 55
2333 CC, Leiden, The Netherlands
Email: beukerspkpd AT lacdr DOT leidenuniv DOT nl <mailto:beukerspkpd_at_lacdr.leidenuniv.nl> Tel: +31-71-5276276

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