From: Moshe Olshansky <m_olshansky_at_yahoo.com>

Date: Thu, 31 Jul 2008 00:11:52 -0700 (PDT)

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https://stat.ethz.ch/mailman/listinfo/r-help PLEASE do read the posting guide http://www.R-project.org/posting-guide.html and provide commented, minimal, self-contained, reproducible code. Received on Thu 31 Jul 2008 - 07:16:50 GMT

Date: Thu, 31 Jul 2008 00:11:52 -0700 (PDT)

You are not specific enough. What do you mean by "significant difference"?
Let's assume that indeed the incidence in A is 6% and in B is 10% and we are looking for Na and Nb such that with probability of at least 80% the mean of Nb sample from B will be at least, say, 0.03 (=3%) above the mean of Na sample from A.
The solution is not unique.

If Mb is the mean of the sample from B and Ma is the one from A, using Normal approximation we get the Mb is approximately normal with mean 0.10 and variance 0.1*0.9/Nb and Ma is approximately normal with mean 0.06 and variance 0.06*0.94/Na, so Mb - Ma is approximately normal with mean 0.04 and variance 0.09/Nb + 0.0564/Na. So let V be the maximal variance for which the probability that a normal rv with mean 0.04 and variance V is above 0.03 equals 0.80 (finding such V is straightforward). Then you must choose Na and Nb which satisfy 0.09/Nb + 0.0564/Na <= V. One such choice is Nb = 2*0.09/V, Na = 2*0.0564/V.

As I said, this solution is only approximate and probably not optimal, so see what other people say.

Regards,

Moshe.

*> From: Iasonas Lamprianou <lamprianou_at_yahoo.com>
**> Subject: [R] stats question
*

> To: r-help@r-project.org

*> Received: Thursday, 31 July, 2008, 2:46 PM
**> Dear friends,
**> I am not sure that this is the right place to ask, but
**> please feel free to suggest an alternative discussion
**> group.
**> My question is that I want to do a comparative study in
**> order to compare the rate of incidence in two populations. I
**> know that a pilot study was conducted a few weeks ago and
**> found 8/140 (around 6%) incidence in population A.
**> Population B was not sampled. Assuming this is (about) the
**> right proportion in the Population A what is the sample
**> size I need for population A and B in the main study, in
**> order to have power of 80% to idenitfy
**> significant differences? I would expect the incidence in
**> population B to be around 10% compared to the 6% of the
**> Population A.
**> Any suggestions? How can I do this in R?
**>
**> Jason
**>
**>
**>
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*

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https://stat.ethz.ch/mailman/listinfo/r-help PLEASE do read the posting guide http://www.R-project.org/posting-guide.html and provide commented, minimal, self-contained, reproducible code. Received on Thu 31 Jul 2008 - 07:16:50 GMT

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