From: <Christian.Stratowa_at_vie.boehringer-ingelheim.com>

Date: Wed 21 Jul 2004 - 21:19:59 EST

}

Christian Stratowa, PhD

Boehringer Ingelheim Austria

Dept NCE Lead Discovery - Bioinformatics Dr. Boehringergasse 5-11

A-1121 Vienna, Austria

Tel.: ++43-1-80105-2470

Fax: ++43-1-80105-2782

email: christian.stratowa@vie.boehringer-ingelheim.com

R-help@stat.math.ethz.ch mailing list

https://www.stat.math.ethz.ch/mailman/listinfo/r-help PLEASE do read the posting guide! http://www.R-project.org/posting-guide.html Received on Wed Jul 21 21:27:52 2004

Date: Wed 21 Jul 2004 - 21:19:59 EST

Any further suggestions would be appreciated very much.

Best regards

Christian Stratowa

Best regards

Christian Stratowa

Searching the web I found the function "compcorr", see: http://www.fon.hum.uva.nl/Service/Statistics/Two_Correlations.html http://ftp.sas.com/techsup/download/stat/compcorr.html and implemented it in R:

compcorr <- function(n1, r1, n2, r2){

# compare two correlation coefficients

# return difference and p-value as list(diff, pval)

# Fisher Z-transform

zf1 <- 0.5*log((1 + r1)/(1 - r1)) zf2 <- 0.5*log((1 + r2)/(1 - r2))

# difference

dz <- (zf1 - zf2)/sqrt(1/(n1 - 3) + (1/(n2 - 3)))

# p-value

pv <- 2*(1 - pnorm(abs(dz))) return(list(diff=dz, pval=pv))

}

Would it make sense to use the resultant p-value to "normalize" the correlation coefficients, using: corr <- corr * compcorr()$pval

Is there a better way or an alternative to "normalize" the correlation coefficients obtained for different tissues?

Thank you in advance for your help.

Since in the company I am not subscribed to bioconductor-help, could you
please reply to me (in addition to bioconductor-help)

P.S.: I have posted this first at r-help and it was suggested to me to post it here, too.

Best regards

Christian Stratowa

Christian Stratowa, PhD

Boehringer Ingelheim Austria

Dept NCE Lead Discovery - Bioinformatics Dr. Boehringergasse 5-11

A-1121 Vienna, Austria

Tel.: ++43-1-80105-2470

Fax: ++43-1-80105-2782

email: christian.stratowa@vie.boehringer-ingelheim.com

R-help@stat.math.ethz.ch mailing list

https://www.stat.math.ethz.ch/mailman/listinfo/r-help PLEASE do read the posting guide! http://www.R-project.org/posting-guide.html Received on Wed Jul 21 21:27:52 2004

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