[R] how to analysis this kind of data set?

From: Xiao Shi <bioconductor.cn_at_gmail.com>
Date: Thu 07 Apr 2005 - 23:50:45 EST


hi,everybody
I have a *time course* data set about a CML cell line treated by two drugs and their combination.The experiment was performed on cDNA microarray platform.The green channel of all the arrays are common,the untreated cell.Here follows the experiment design:

a_0hr,a_3hr,a_8hr,a_12hr,a_24hr,a_48hr,a_72hr, b_3hr,b_8hr,b_12hr,b_24hr,b_48hr,b_72hr, ab_3hr,ab_8hr,ab_12hr,ab_24hr,ab_48hr,ab_72hr.

A total of 19 *cDNA microarrays*.a_0hr means* *drug *a *treament *0 hours vs. control. *And a_3hrs means drug a treatment 3 hours vs. control.So for drug *b *and their combination *ab*(drug a and drug b added together).My goal is to identify the three sets of genes,the genes differentially expressed by drug a,the genes by drug b ,and their combination.  i am thinking about *ANOVA* ,but i am not sure whether it is correct. Any comments,suggestions?Any R/bioconductor packages can be used?Thanks in advance

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