From: Chun-Ying Lee <u9370004_at_cc.kmu.edu.tw>

Date: Wed 20 Jul 2005 - 12:26:25 EST

R-help@stat.math.ethz.ch mailing list

https://stat.ethz.ch/mailman/listinfo/r-help PLEASE do read the posting guide! http://www.R-project.org/posting-guide.html Received on Wed Jul 20 12:35:41 2005

Date: Wed 20 Jul 2005 - 12:26:25 EST

Hi,

regards,

---Chun-ying Lee

*>
*

> Hmm, sorry, no. I'm talking through a hole in my head there.

*>
**> Vm*y/(Km+y) makes OK sense. Vm is what you get for large y - passing
**> from 1st order to 0th order kinetics. However, looking at the data
**>
**> plot(PKindex)
**> abline(lm(conc~time,data=PKindex))
**>
**> shows that they are pretty much on a straight line, i.e. you are
**> in the domain of 0-order kinetics. So why are you expecting the rate
**> of decrease to have changed by roughly 3/4 (from 2/3*Vm/Vd at y=2*Km
**> to 1/2*Vm/Vd at y=Km when you reach 4.67)??
**>
*

R-help@stat.math.ethz.ch mailing list

https://stat.ethz.ch/mailman/listinfo/r-help PLEASE do read the posting guide! http://www.R-project.org/posting-guide.html Received on Wed Jul 20 12:35:41 2005

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