[R] linkage disequilibrium

From: Cristian <cristian_at_biometria.univr.it>
Date: Fri 05 Aug 2005 - 03:36:35 EST


Dear all,

I'm using the package "Genetics", and I'm interested in the computation of D' statistics for Linkage Disequilibrium, for which the LD() command has been realised. Unfortunately I don't find any reference on "how" the D' is computed by the LD() function. In the package documentation it is generally referred as "MLE" estimation, but references are not provided. Does anybody knows how it is obtained or, at least, some references?

Are there any other R package performing the D' computation both for phased and unphased genotype?

Thanks!
Cristian



Cristian Pattaro
Unit of Epidemiology & Medical Statistics Department of Medicine and Public Health University of Verona, Italy


Biometria - biometria.univr.it

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