[R] measurement error model - "simple" linear regression

From: Troels Ring <tring_at_gvdnet.dk>
Date: Mon 17 Oct 2005 - 06:40:17 EST


Dear friends, I found the thread on this subject this summer but wonder whether it has been taken any further. I have an important medical problem where X is computed from a three independent and complicated measurements (exchangeable sodium and potassium and total body water - i.e. X = (Nae+Ke)/TBW ) and Y is serum sodium concentration (all data in Edelman, JCI 1958). I have the individual data in the paper (but have not yet had time to enter it) and Edelman et al in fact reported measurement errors for most individual items. Edelman and coworkers made a linear regression of Y on X and now I would like to ascertain the importance of the fact that X was measured with error for the utility of the formula in clinical practice (since I believe it is being misused by ignoring this fact - and more). I found in Neter, Wasserman and Kutner 3. ed a general discussion of the problem - but would very much like a more recent presentation if available and application in R.

Best wishes

Troels Ring
Aalborg, Denmark



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