From: Frank E Harrell Jr <f.harrell_at_vanderbilt.edu>

Date: Thu 09 Feb 2006 - 04:20:26 EST

Date: Thu 09 Feb 2006 - 04:20:26 EST

Cox, Stephen wrote:

> Please forgive a rather naïve question...

*>
**> Could someone please give a quick explanation for the differences in conf intervals achieved via confint.glm (based on profile liklihoods) and the intervals achieved using the Design library.
**>
**> For example, the intervals in the following two outputs are different.
**>
**> library(Design)
**> x = rnorm(100)
**> y = gl(2,50)
**> d = data.frame(x = x, y = y)
**> dd = datadist(d); options(datadist = 'dd')
**> m1 = lrm(y~x, data = d)
**> summary(m1)
**>
**> m2 = glm(y~x, family = binomial, data = d)
**> confint(m2)
**>
**> I have spent time trying to figure this out via archives, but have not had much luck.
**>
**> Regards
**>
**> Stephen
*

Design uses Wald(large sample normality of parameter estimates) -based confidence intervals. These are good for most situations but profile confidence intervals are preferred. Someday I'll make Design do those.

One advantage to Wald statistics is that they extend readily to cluster sampling (e.g., using cluster sandwich covariance estimators) and other complications (e.g., adjustment of variances for multiple imputation), whereas likelihood ratio statistics do not (unless e.g. you have an explicit model for the correlation structure or other facits of the model).

Also note that confint is probably giving a confidence interval for a one-unit change in x whereas summary.Design is computing an interquartile-range effect (difference in x-values is shown in the summary output).

When posting a nice simulated example it's best to do set.seed(something) so everyone will get the same data.

Frank

-- Frank E Harrell Jr Professor and Chair School of Medicine Department of Biostatistics Vanderbilt University ______________________________________________ R-help@stat.math.ethz.ch mailing list https://stat.ethz.ch/mailman/listinfo/r-help PLEASE do read the posting guide! http://www.R-project.org/posting-guide.htmlReceived on Thu Feb 09 05:53:26 2006

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