[R] query: sample size calculation

From: <ManuelPerera-Chang_at_fmc-ag.com>
Date: Fri 26 May 2006 - 22:57:02 EST

Dear all,

I am doing something wrong.

I am trying to apply a formula for sample size calculation as in the book "Design and Analysis of Clinical Trials", from Chow et all.

There a suggested sample size strategy uses the formula


which gives n=96, as in the book.

(here F(alfa,k,n) is the upper (alfa)th quantile of an F distribution with k,n degrees of freedom)

I have been trying to get n=96 using the following code in R.

 for (n in 1:200) {
  val[n]<- qf(0.8, 2*n, 2*n,lower.tail = TRUE, log.p = FALSE)/qf(0.025,
2*n, 2*n,lower.tail = TRUE, log.p = FALSE);  }

but val doesnot get any close to 0.30/0.45.

Thank you,


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